Understanding COVID-19 Immunity in Pregnant Mothers and Their Babies
SARS-CoV-2 in Pregnancy: Comparison of Natural Infection and Hybrid Immunity in Mother-Infant Pairs
This project looks at how pregnant mothers and their babies develop protection against COVID-19, comparing natural infection with a combination of infection and vaccination.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11135473 on NIH RePORTER |
What this research studies
We want to learn more about how pregnant mothers and their babies build immunity to COVID-19. This project compares the immune responses from natural infection to those from a "hybrid immunity" which combines both infection and vaccination. We are especially interested in how this protection passes from mother to baby and lasts over time. This information will help us understand the long-term effects and the best ways to protect mothers and their infants from severe COVID-19.
Who could benefit from this research
Good fit: This project focuses on mother-infant pairs who experienced SARS-CoV-2 infection during pregnancy, some of whom also received COVID-19 vaccination.
Not a fit: Patients who have not been pregnant or had SARS-CoV-2 infection during pregnancy would not directly benefit from participating in this specific project.
Why it matters
Potential benefit: If successful, this work could help guide recommendations for vaccination strategies in pregnant individuals to better protect both mothers and their newborns from COVID-19.
How similar studies have performed: While previous studies have looked at natural infection or vaccine-induced immunity separately, this project explores the less understood area of hybrid immunity in pregnancy.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Cambou, Mary Catherine — University of California Los Angeles
- Study coordinator: Cambou, Mary Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.