Understanding complex DNA mutations in ovarian cancer
Inferring the structure and evolution of tandem duplication towers
This study is looking at specific changes in DNA that can lead to ovarian cancer, and it's for anyone interested in understanding how these changes affect the disease and treatment options.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10843826 on NIH RePORTER |
What this research studies
This research investigates complex structural variants in DNA, particularly focusing on how these mutations can drive ovarian cancer. By developing new computational tools, the study aims to analyze long-range and single-cell genomic profiles to better understand these mutations. The researchers will create genome graphs to characterize the allelic structure of a specific mutation pattern known as pyrgo, which is prevalent in ovarian adenocarcinomas. This approach will help identify how these mutations relate to cancer characteristics and treatment history.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with ovarian adenocarcinoma who may have complex structural variants in their DNA.
Not a fit: Patients with non-cancerous conditions or those without structural DNA mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for ovarian cancer patients.
How similar studies have performed: Previous research has shown promise in using computational tools to analyze complex DNA mutations, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Choo, Zi-Ning — Weill Medical Coll of Cornell Univ
- Study coordinator: Choo, Zi-Ning
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.