Understanding communication between different regions in human organoid models using light-based techniques
Official title: Dissecting inter-region communication in human organoid models with dual-color optogenetic probes
Funded at University of Massachusetts Amherst · NIH-11058502 · Data updated 2026-11-12
This study is exploring new ways to create tiny brain models to better understand how different parts of the brain work together in people with autism, using special light techniques to see how brain cells communicate.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $223,166 |
| NIH project number | 5R21AG087754-02 |
| Project ID | NIH-11058502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or those at risk of developing it.
✕Less likely to help
Patients without autism spectrum disorder or related developmental conditions may not benefit from this research.
What this research studies
This research focuses on developing advanced organoid models that mimic human brain structures to study autism spectrum disorder. By using dual-color optogenetic probes, researchers aim to investigate how different regions of these organoids communicate with each other. The approach involves creating interconnected compartments within the organoids and using light to control and measure cell activity with high precision. This could lead to a better understanding of the functional connectivity and maturation of brain tissues affected by autism.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of autism and potentially lead to new therapeutic strategies.
How similar studies have gone: Previous research using optogenetic techniques in organoid models has shown promising results, indicating that this approach could be effective.
Where this research is happening
-
University of Massachusetts Amherst
Hadley, United States Active
Researchers
- Principal investigator: Xu, Guangyu — University of Massachusetts Amherst
- Study coordinator: Xu, Guangyu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.