Understanding colorectal cancer outcomes in Nigeria compared to the US
Research Project
This study is looking at why people with colorectal cancer in Nigeria may have different outcomes compared to those in the United States, focusing on the biology of their tumors, to help improve treatment options like immunotherapy for patients in Nigeria and similar countries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10879524 on NIH RePORTER |
What this research studies
This research investigates the differences in colorectal cancer outcomes between patients in Nigeria and those in the United States. It focuses on understanding the biological factors contributing to poorer outcomes in Nigerian patients, particularly examining the role of microsatellite instability in tumors. The project aims to create a comprehensive dataset and biobank that will facilitate future studies on immunotherapy for colorectal cancer in low- and middle-income countries. By comparing the tumor immune microenvironment of Nigerian patients to a reference group from the US, the research seeks to identify potential benefits of immunotherapy for these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are colorectal cancer patients from Nigeria, particularly those with microsatellite instability in their tumors.
Not a fit: Patients with colorectal cancer from high-income countries or those without microsatellite instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for colorectal cancer patients in Nigeria through the application of immunotherapy.
How similar studies have performed: Other research has shown promising results in applying immunotherapy to similar patient populations, indicating potential for success in this novel approach.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Kingham, T Peter — Sloan-Kettering Inst Can Research
- Study coordinator: Kingham, T Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.