Understanding cognitive impairment in older adults with HIV in Uganda
Official title: Clinical Spectrum and Societal Impact of Cognitive Impairment with HIV in Uganda
Funded at Massachusetts General Hospital · NIH-11124415 · Data updated 2026-11-12
This study is looking at how HIV affects memory and thinking skills in older adults in Uganda, comparing those with HIV to those without, to help us understand the risks of mild cognitive impairment and Alzheimer's in this group.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,103,953 |
| NIH project number | 1R56AG087790-01 |
| Project ID | NIH-11124415 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 60 and above living with HIV in Uganda, as well as demographically similar HIV-negative individuals.
✕Less likely to help
Patients who are younger than 60 years old or those without HIV may not receive direct benefits from this research.
What this research studies
This research investigates the risk factors and causes of mild cognitive impairment (MCI) and Alzheimer's related dementia (ADRD) among older adults living with HIV in Uganda. It employs advanced techniques such as neuropsychological assessments, brain imaging, and machine learning to better understand the cognitive health of this population. The study aims to compare cognitive decline trajectories between older adults with HIV and similar-aged individuals without HIV, providing a comprehensive view of the impact of HIV on cognitive health. By focusing on a demographic that has been underrepresented in previous studies, this research seeks to fill critical gaps in knowledge regarding cognitive health in sub-Saharan Africa.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive impairment in older adults living with HIV, ultimately enhancing their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding cognitive impairment in HIV populations, but this study aims to explore this area in a novel context with older adults in Uganda.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Siedner, Mark J — Massachusetts General Hospital
- Study coordinator: Siedner, Mark J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.