Understanding cognitive impairment in older adults with HIV in Uganda
Clinical Spectrum and Societal Impact of Cognitive Impairment with HIV in Uganda
This study is looking at how HIV affects memory and thinking skills in older adults in Uganda, comparing those with HIV to those without, to help us understand the risks of mild cognitive impairment and Alzheimer's in this group.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11124415 on NIH RePORTER |
What this research studies
This research investigates the risk factors and causes of mild cognitive impairment (MCI) and Alzheimer's related dementia (ADRD) among older adults living with HIV in Uganda. It employs advanced techniques such as neuropsychological assessments, brain imaging, and machine learning to better understand the cognitive health of this population. The study aims to compare cognitive decline trajectories between older adults with HIV and similar-aged individuals without HIV, providing a comprehensive view of the impact of HIV on cognitive health. By focusing on a demographic that has been underrepresented in previous studies, this research seeks to fill critical gaps in knowledge regarding cognitive health in sub-Saharan Africa.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 60 and above living with HIV in Uganda, as well as demographically similar HIV-negative individuals.
Not a fit: Patients who are younger than 60 years old or those without HIV may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive impairment in older adults living with HIV, ultimately enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding cognitive impairment in HIV populations, but this study aims to explore this area in a novel context with older adults in Uganda.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Siedner, Mark J — Massachusetts General Hospital
- Study coordinator: Siedner, Mark J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.