Understanding Cognitive Changes in Multiple Sclerosis Using Advanced Brain Imaging
Multi-Scale, Multi-Modal Imaging Assessment of Trajectories of Cognitive Impairment in Multiple Sclerosis
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11163499
This research aims to better understand why some people with multiple sclerosis experience memory and thinking problems by looking closely at their brain changes over time.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11163499 on ClinicalTrials.gov |
What this research studies
Many people with multiple sclerosis (MS) find that their memory and thinking skills change as their disease progresses, and currently, there are no approved treatments specifically for these cognitive symptoms. This project uses advanced brain imaging, including MRI and PET scans, to get a detailed look at how brain networks and individual brain cells are affected in MS. By combining these different imaging techniques and following patients over time, we hope to uncover the specific brain changes that lead to cognitive decline. Our goal is to create tools that can help identify patients at risk for these changes, paving the way for more personalized treatments in the future.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would be individuals living with multiple sclerosis who are experiencing or are at risk for cognitive impairment.
Not a fit: Patients without multiple sclerosis or those not experiencing cognitive symptoms related to MS may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify patients with MS at risk for cognitive decline and help develop targeted treatments to preserve their thinking abilities.
How similar studies have performed: While brain network studies have linked imaging findings to cognitive impairment in MS, this research aims to resolve conflicting findings and understand the direction of these changes, suggesting a novel approach to an unresolved question.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAUTHIER, SUSAN A — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: GAUTHIER, SUSAN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.