Understanding cognitive changes and dementia in older adults

Adult Changes in Thought (ACT) Research Program

NIH-funded research Kaiser Foundation Research Institute · NIH-11124761

The ACT Program is looking for older adults aged 65 and up to help us learn more about memory changes and dementia, especially Alzheimer's, so we can find better ways to keep our minds healthy as we age.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionKaiser Foundation Research Institute NIH-funded
Lab location1 site (Oakland, UNITED STATES)
Project IDNIH-11124761 on NIH RePORTER

What this research studies

The Adult Changes in Thought (ACT) Program aims to enhance our understanding of cognitive changes and dementia, particularly Alzheimer's disease, in older adults. This research involves tracking individuals aged 65 and older within a healthcare system to identify new cases of dementia and follow participants through various assessments, including autopsy. The study focuses on expanding participant diversity and collecting detailed data on life course risk factors, cognitive abilities, and physical health to identify potential interventions for preserving cognitive function. By modernizing the existing cohort study, the ACT Program seeks to provide valuable insights into the prevention and treatment of dementia-related conditions.

Who could benefit from this research

Good fit: Ideal candidates for participation are individuals aged 65 and older, particularly those from diverse racial and ethnic backgrounds.

Not a fit: Patients under the age of 65 or those with pre-existing severe cognitive impairment may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for preventing cognitive decline and Alzheimer's disease in older adults.

How similar studies have performed: Previous research has shown success in understanding dementia through cohort studies, making this approach both promising and well-supported by existing literature.

Where this research is happening

Oakland, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.