Understanding cognitive challenges in older adults with HIV
Executive Function Impairments in HAND and Aging
This study is looking at how getting older affects thinking skills in older adults with HIV, and it aims to find new treatments that could help improve their brain function and slow down any decline.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11196189 on NIH RePORTER |
What this research studies
This research investigates how aging affects cognitive function in older adults living with HIV. It focuses on the neurocognitive impairments that are more prevalent in this population compared to younger individuals. The study aims to develop innovative therapies that target specific neuronal injuries caused by HIV, potentially restoring cognitive function. By using a unique approach that involves dendritic spine-targeted therapeutics, the research seeks to delay the progression of cognitive decline associated with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults over the age of 50 who are HIV-positive and experiencing cognitive impairments.
Not a fit: Patients who are younger than 50 or those who do not have HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments that improve cognitive function and quality of life for older adults living with HIV.
How similar studies have performed: Previous research has shown promise in targeting neurocognitive impairments in HIV, but this specific dendritic spine-targeted approach is relatively novel.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Mactutus, Charles F. — University of South Carolina at Columbia
- Study coordinator: Mactutus, Charles F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.