Understanding cognitive challenges in childhood leukemia survivors
Identification of causal factors underlying cognitive deficits in a mouse model of childhood leukemia survival
This study is looking at how the chemotherapy drug methotrexate might affect the thinking and learning abilities of kids who survived childhood leukemia, with the hope of finding ways to help them have a better quality of life as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10904841 on NIH RePORTER |
What this research studies
This research investigates the cognitive deficits that may arise in survivors of childhood acute lymphoblastic leukemia (ALL), particularly focusing on how the chemotherapy drug methotrexate affects brain development and function. Using a mouse model that mimics leukemia treatment, the study aims to identify the biological mechanisms linking chemotherapy to cognitive issues, especially in areas like attention and planning. By examining the effects of chemotherapy on brain inflammation and development, the research seeks to inform strategies that could help improve the quality of life for survivors as they grow into adulthood.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents who have survived acute lymphoblastic leukemia and are experiencing cognitive challenges.
Not a fit: Patients who have not undergone treatment for acute lymphoblastic leukemia or those without cognitive deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to interventions that protect the cognitive health of childhood leukemia survivors, enhancing their quality of life.
How similar studies have performed: Previous research has shown that understanding the effects of chemotherapy on cognitive function in childhood cancer survivors can lead to meaningful interventions, indicating that this approach has potential for success.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Reyes, Teresa M — University of Cincinnati
- Study coordinator: Reyes, Teresa M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.