Understanding Classic Bartter Syndrome
Exploring the pathogenesis of classic Bartter syndrome
This research aims to uncover why classic Bartter syndrome develops, focusing on how kidney cells grow and function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11162526 on NIH RePORTER |
What this research studies
Classic Bartter syndrome is a kidney condition caused by specific gene changes, but we don't fully understand why it affects people so differently. While it was thought that the problem was just with how kidney cells handle salt, our recent findings suggest that the kidney tubules might not develop properly from the start. This project will look closely at how kidney cells grow and divide, and how their energy systems (mitochondria) work, to see if these issues contribute to the condition.
Who could benefit from this research
Good fit: Patients with classic Bartter syndrome may ultimately benefit from the new insights gained from this fundamental research.
Not a fit: Individuals without classic Bartter syndrome would not directly benefit from the findings of this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of classic Bartter syndrome, potentially paving the way for new and more effective treatments.
How similar studies have performed: This project builds on recent findings that challenge previous assumptions about Bartter syndrome, suggesting a novel approach to understanding its origins.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Cheng, Chih-Jen — University of Iowa
- Study coordinator: Cheng, Chih-Jen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.