Understanding circular RNAs in head and neck cancer
Official title: Regulation and Function of Viral and Endogenous Circular RNA in Cancer
Funded at Ut Southwestern Medical Center · NIH-10877970 · Data updated 2026-11-12
This study is looking at special RNA molecules in head and neck cancer, especially in patients with HPV, to learn how they might affect the cancer's growth and behavior, which could help us understand the disease better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $557,189 |
| NIH project number | 5R01CA275071-02 |
| Project ID | NIH-10877970 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with head and neck squamous cell carcinoma, particularly those with HPV-related tumors.
✕Less likely to help
Patients with cancers unrelated to head and neck squamous cell carcinoma or those without HPV involvement may not benefit from this research.
What this research studies
This research investigates the role of circular RNAs (circRNAs) in head and neck squamous cell carcinoma (HNSCC), particularly those derived from the human papillomavirus (HPV). The team aims to uncover how these circRNAs function and are regulated, which could reveal new insights into cancer development. By analyzing tumor samples from patients with both HPV-positive and HPV-negative HNSCC, the researchers will utilize advanced sequencing techniques to profile these RNA molecules. This comprehensive approach may lead to a better understanding of the molecular mechanisms driving this type of cancer.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic and therapeutic strategies for patients with head and neck cancer.
How similar studies have gone: Previous research has shown promising results in understanding the role of circRNAs in various cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Wang, Richard C — Ut Southwestern Medical Center
- Study coordinator: Wang, Richard C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.