Understanding Circular RNAs in Alzheimer's Disease
Multimodal Characterization of the Role of Circular RNAs in Alzheimer's Disease
This research looks at special genetic signals called circular RNAs in brain and blood samples to better understand Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11297454 on NIH RePORTER |
What this research studies
Our bodies have tiny genetic instructions called RNAs, and this project focuses on a less-understood type called circular RNAs (circRNAs). We are examining brain tissue from many individuals, including those with Alzheimer's and those without, to find specific circRNAs linked to the disease. We also plan to look at circRNAs in blood samples from people with Alzheimer's to see if they could serve as early warning signs or markers. Finally, we will conduct lab experiments to learn how a particular circRNA, circHOMER1, might contribute to Alzheimer's disease processes.
Who could benefit from this research
Good fit: This research primarily uses donated brain and blood samples from individuals with Alzheimer's disease and healthy controls.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not receive benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict, diagnose, or even treat Alzheimer's disease by targeting these circular RNAs.
How similar studies have performed: Our team has already identified specific circular RNAs linked to Alzheimer's risk and disease features in previous studies, suggesting this approach is promising.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cruchaga, Carlos — Washington University
- Study coordinator: Cruchaga, Carlos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.