Understanding Circadian Rhythms and Beta-cell Health in Type 2 Diabetes
Role of Circadian Misalignment in Beta-cell Failure in Type 2 Diabetes
This research explores how disruptions to our daily body clock might lead to problems with insulin-producing cells in people with Type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11118860 on NIH RePORTER |
What this research studies
For people with Type 2 diabetes, the cells in the pancreas that make insulin, called beta-cells, often stop working properly. This can lead to issues like not making enough insulin or losing their ability to function correctly. We are looking into how changes in our daily routines, like sleep and meal times, which affect our body's natural rhythms, might contribute to these beta-cell problems. Our goal is to understand the specific ways these daily rhythm disruptions impact beta-cell health and insulin production.
Who could benefit from this research
Good fit: This foundational research is for individuals interested in the underlying causes of Type 2 diabetes and how daily rhythms affect their health.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find this basic science research directly beneficial in the short term.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Type 2 diabetes by protecting the insulin-producing cells.
How similar studies have performed: While the link between circadian disruption and glucose intolerance is known, the specific molecular mechanisms connecting it to beta-cell failure and ER proteostasis are still being uncovered.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Matveyenko, Aleksey V — Mayo Clinic Rochester
- Study coordinator: Matveyenko, Aleksey V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.