Understanding chronic traumatic encephalopathy and related dementias
Official title: Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II
Funded at Boston University Medical Campus · NIH-10985074 · Data updated 2026-11-12
This study is looking at chronic traumatic encephalopathy (CTE) and similar types of dementia to understand how they develop and what factors might help protect against them, and it’s for people who want to learn more about their health through regular check-ups and tests like MRIs and blood work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $3,289,394 |
| NIH project number | 1R01NS139383-01 |
| Project ID | NIH-10985074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include former athletes, particularly those who have experienced repetitive head impacts, as well as individuals with symptoms of dementia.
✕Less likely to help
Patients who have not been exposed to repetitive head impacts or do not exhibit symptoms of dementia may not benefit from this research.
What this research studies
This research investigates chronic traumatic encephalopathy (CTE) and related dementias by examining clinical presentations and biomarker profiles. It aims to identify risk and resilience factors associated with CTE, particularly focusing on social determinants of health. The study will involve longitudinal assessments, including clinical exams, MRI scans, and blood tests, to better understand how these conditions develop and progress over time. Participants will be followed up remotely to gather comprehensive data on their health.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and treatment options for individuals affected by CTE and related dementias.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Alosco, Michael — Boston University Medical Campus
- Study coordinator: Alosco, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.