Understanding Chronic Sinus Inflammation
Mentoring in Chronic Rhinosinusitis Pathophysiology and Mechanisms of Disease
This project aims to better understand different types of chronic sinus inflammation in people to help develop more personalized treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11174425 on NIH RePORTER |
What this research studies
Chronic rhinosinusitis (CRS) is a common inflammatory condition that significantly impacts quality of life for many people. Our team is working to identify different patterns of inflammation within large groups of CRS patients. By understanding these distinct patterns, called endotypes, we hope to create more tailored and effective treatment plans. This involves enrolling CRS patients to collect biospecimens and track how their inflammatory markers and endotypes change over time and in relation to their sinus microbes. We also want to see how common treatments affect these inflammatory patterns.
Who could benefit from this research
Good fit: Ideal candidates would be adults aged 21 years or older who have chronic rhinosinusitis and are willing to participate in a prospective translational cohort study.
Not a fit: Patients who do not have chronic rhinosinusitis or are not interested in contributing biospecimens for research may not directly benefit from this specific research opportunity.
Why it matters
Potential benefit: If successful, this work could lead to more precise diagnoses and personalized treatment approaches for individuals suffering from chronic rhinosinusitis.
How similar studies have performed: This project builds upon existing knowledge and a well-established biospecimen repository, while also exploring the longitudinal stability of CRS endotypes and the effects of interventions, which is a novel aspect.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Turner, Justin H — University of Alabama at Birmingham
- Study coordinator: Turner, Justin H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.