Understanding chronic pain after surgery and its treatment

Chronic Postsurgical Pain Across the Lifespan: Brain State and Treatment

NIH-funded research Massachusetts General Hospital · NIH-10884260

This study is looking into why some people experience ongoing pain after surgery and aims to find out how different factors like biology, emotions, and social situations play a role, so we can create better ways to prevent and treat this pain for everyone, no matter their age.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionMassachusetts General Hospital NIH-funded
Lab location1 site (Boston, United States)
Project IDNIH-10884260 on NIH RePORTER

What this research studies

This research investigates chronic post-surgical pain (CPSP), which affects many patients for months after surgery. It aims to identify the biological, psychological, and social factors that contribute to CPSP across different age groups. By integrating clinical data and brain measures, the research seeks to develop effective treatment strategies and preventive measures for CPSP. The study will utilize both clinical and animal models to explore these factors over a five-year period.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals who have undergone surgery and are experiencing persistent pain lasting longer than two months.

Not a fit: Patients who have not had surgery or those whose pain is unrelated to surgical procedures may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment options and preventive strategies for patients suffering from chronic pain after surgery.

How similar studies have performed: Previous research has shown promise in understanding chronic pain mechanisms, indicating that this approach could yield valuable insights.

Where this research is happening

Boston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.