Understanding chronic pain after surgery
Official title: IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain after Surgery
Funded at Washington University · NIH-11043819 · Data updated 2026-11-12
This study is looking into why some people experience long-lasting pain after surgery, hoping to find better ways to predict and treat this pain by exploring how different factors like biology and psychology play a role.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $4,618,885 |
| NIH project number | 1RM1NS135283-01A1 |
| Project ID | NIH-11043819 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are undergoing or have recently undergone major surgical procedures.
✕Less likely to help
Patients who have not had surgery or those with acute pain conditions may not benefit from this research.
What this research studies
This research investigates chronic postsurgical pain (CPSP), which affects nearly 20% of patients after major surgery. It aims to uncover the complex biological mechanisms behind CPSP by integrating insights from various fields such as pain neurobiology, psychology, and genomics. The study will analyze how different factors contribute to the diverse experiences of pain among patients, using advanced techniques like machine learning and bioinformatics. By understanding these mechanisms, the research seeks to improve predictions and treatments for CPSP.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for predicting, preventing, and treating chronic pain after surgery.
How similar studies have gone: Previous research has shown promise in understanding chronic pain mechanisms, but this integrated approach is relatively novel and aims to fill existing gaps.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Haroutounian, Simon — Washington University
- Study coordinator: Haroutounian, Simon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.