Understanding chromosome issues in mammalian embryos
Comparative Analysis of Aneuploidy and Cellular Fragmentation Dynamics in Mammalian Embryos
This study looks at how mistakes in chromosome numbers can affect embryo growth and lead to miscarriages, and it aims to help us understand these issues better by comparing different animals like humans and cows.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11060043 on NIH RePORTER |
What this research studies
This research investigates how errors in chromosome numbers, known as aneuploidy, affect embryo development and contribute to miscarriages in mammals. By comparing different species, including humans and cattle, the study aims to uncover the mechanisms behind these chromosome errors and their relationship with cellular fragmentation, a process where parts of the embryo break off. The research employs advanced genetic analysis techniques to explore these dynamics in various mammalian embryos, which could lead to better understanding and potential solutions for reproductive challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing assisted reproductive technologies who may be at risk for miscarriage due to chromosomal abnormalities.
Not a fit: Patients who are not seeking assisted reproductive technologies or who do not have a history of miscarriage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved reproductive outcomes and reduced miscarriage rates in assisted reproduction.
How similar studies have performed: Previous research has shown promising results in understanding aneuploidy in human and non-human primate embryos, indicating that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Chavez, Shawn L. — Oregon Health & Science University
- Study coordinator: Chavez, Shawn L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.