Understanding chromosome errors in embryonic stem cells
Causes and Consequences of Aneuploidy in HeSCs
['FUNDING_R01'] · DARTMOUTH COLLEGE · NIH-10807116
This study is looking at how mistakes in cell division can lead to problems like miscarriages and birth defects, using human embryonic stem cells to better understand what goes wrong during early development.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-10807116 on ClinicalTrials.gov |
What this research studies
This research investigates how errors in chromosome segregation during cell division lead to aneuploidy, which is a common cause of miscarriages and birth defects. By using human embryonic stem cells, the researchers aim to identify the specific pathways that cause these errors and how they affect the development of embryos. The study employs advanced imaging techniques and genomic analysis to explore these mechanisms, which could ultimately improve our understanding of early human development and reproductive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing recurrent miscarriages or those with a history of congenital abnormalities in their offspring.
Not a fit: Patients who have not experienced miscarriages or congenital defects may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for miscarriages and congenital defects.
How similar studies have performed: Other research has shown success in understanding chromosome segregation errors in various cell types, but this specific focus on embryonic stem cells is relatively novel.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GODEK, KRISTINA M — DARTMOUTH COLLEGE
- Study coordinator: GODEK, KRISTINA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.