Understanding chromosome changes in cancer
Epigenomic consequences of breakage-fusion-bridge cycling
This project aims to understand how chromosomes break and rearrange in cancer cells, using a plant model to uncover new insights.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11145952 on NIH RePORTER |
What this research studies
We are exploring a process called the breakage-fusion-bridge (BFB) cycle, which is common in cancer and leads to significant changes in chromosomes. This cycle can cause parts of chromosomes to be copied or shattered, contributing to how tumors grow and become more aggressive. Our work uses a special system in maize (corn) to study these complex chromosome changes, as maize allows us to observe these events more easily. We believe that these chromosome changes also lead to important shifts in how genes are regulated, similar to what is seen in many human cancers. By understanding these fundamental processes, we hope to learn more about how cancer develops.
Who could benefit from this research
Good fit: This foundational biological work does not directly involve patients, but future cancer patients could benefit from the knowledge gained.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new basic mechanisms of cancer development, potentially leading to new targets for future cancer treatments.
How similar studies have performed: The breakage-fusion-bridge cycle was first described in maize decades ago, and this project builds on that foundational knowledge to explore its epigenetic consequences in a cancer context.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Dawe, R. Kelly — University of Georgia
- Study coordinator: Dawe, R. Kelly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.