Understanding chromosomal abnormalities in early embryo development
Official title: Characterization of aneuploidy, cell fate and mosaicism in early development
Funded at University of Washington · NIH-10899618 · Data updated 2026-11-12
This study looks at how certain chromosomal issues in embryos can affect their development, using marmosets to help us understand why these problems often lead to early miscarriages, which could eventually help improve pregnancy outcomes for people trying to conceive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 4, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $229,562 |
| NIH project number | 5R00HD107219-04 |
| Project ID | NIH-10899618 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing recurrent miscarriages or those undergoing in vitro fertilization who may have concerns about embryo viability.
✕Less likely to help
Patients who are not undergoing fertility treatments or who do not have a history of chromosomal abnormalities in embryos may not benefit from this research.
What this research studies
This research investigates the impact of chromosomal abnormalities, known as aneuploidy, on early embryo development using a common marmoset model. By studying these abnormalities, which are a leading cause of early miscarriages, the research aims to uncover the cellular and molecular mechanisms that dictate the fate of aneuploid cells during development. The approach involves analyzing how these cells behave and differentiate in response to specific stimuli, providing insights that could improve reproductive outcomes. The findings could help in understanding the high rates of miscarriage associated with in vitro fertilization and natural conception.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for embryo selection and enhanced reproductive success for individuals undergoing assisted reproduction.
How similar studies have gone: Previous research has shown promising results in understanding aneuploidy through animal models, but this specific approach using marmosets is relatively novel.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Yang, Min — University of Washington
- Study coordinator: Yang, Min
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.