Understanding Chlamydia pneumoniae and Alzheimer's Disease
The role of Chlamydia pneumoniae infection in Alzheimer's Disease
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-11126028
This research explores how a common infection, Chlamydia pneumoniae, might contribute to the development and progression of Alzheimer's Disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11126028 on ClinicalTrials.gov |
What this research studies
Alzheimer's Disease is a devastating condition affecting millions, and while much research has been done, slowing or curing it remains a challenge. Scientists are now looking back at the idea that infections could play a role in this disease. This particular project focuses on Chlamydia pneumoniae, a common bacteria linked to other chronic inflammatory conditions, which has been found in the brains of some Alzheimer's patients. We want to understand the exact ways this infection might change how Alzheimer's develops.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly but aims to benefit individuals at risk for or living with Alzheimer's Disease in the future.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical trial will not find a direct benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Alzheimer's Disease by targeting specific infections or their effects.
How similar studies have performed: While the idea of infections contributing to Alzheimer's has been explored before, this specific focus on Chlamydia pneumoniae and its mechanisms is a novel and largely untested approach in definitive mouse models.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CROTHER, TIMOTHY ROBERT — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: CROTHER, TIMOTHY ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia