Understanding Childhood Leukemia with Patient Cells
Therapeutic insights through patient derived leukemia xenografts
This work uses cells from children with leukemia to create models that help us learn more about the disease and find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11123416 on NIH RePORTER |
What this research studies
Researchers are creating special models using leukemia cells donated by patients to better understand how childhood leukemia develops and behaves. These models help overcome limitations of traditional animal models by more closely reflecting human disease. By studying these patient-derived models, scientists hope to uncover the specific genetic changes and mechanisms that drive different types of leukemia. This approach allows for a more accurate way to test potential new treatments and predict how they might work in patients.
Who could benefit from this research
Good fit: This research is relevant to children diagnosed with leukemia, as it uses their cells to create models for understanding the disease.
Not a fit: Patients whose conditions are not related to childhood leukemia would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of childhood leukemia, helping to identify new targets for therapies and ultimately improve treatment options for children.
How similar studies have performed: Using patient-derived models is a well-established and advancing approach in cancer research, with many studies showing success in identifying disease mechanisms and potential therapies.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Wunderlich, Mark — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Wunderlich, Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.