Understanding Chiari Type I Malformation through Genetic and Clinical Profiles
Official title: Redefining Chiari Type I Malformation through Genetically, Radiologically, and Clinically-Derived Endophenotypes that are Predictive of Long-Term Neurological Outcome
Funded at Washington University · NIH-10876289 · Data updated 2026-11-12
This study is looking at Chiari Type I Malformation to understand its different types and how they affect people, so we can improve care and predict long-term outcomes for patients like you.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $185,734 |
| NIH project number | 5P01NS131131-02 |
| Project ID | NIH-10876289 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Chiari Type I Malformation, regardless of symptom severity.
✕Less likely to help
Patients with Chiari Type I Malformation who are asymptomatic and do not wish to participate in genetic or clinical evaluations may not benefit from this research.
What this research studies
This research investigates Chiari Type I Malformation (CM), a condition where brain tissue extends into the spinal canal, by examining genetic, radiological, and clinical data to create detailed profiles of the disease. The study aims to identify different subtypes of CM that may present with varying symptoms and outcomes, using advanced imaging and genomic techniques. By classifying these subtypes, the research seeks to improve clinical management and predict long-term neurological outcomes for patients. Patients will be assessed through a combination of clinical evaluations and genetic testing to better understand their specific condition.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans and improved long-term outcomes for patients with Chiari Type I Malformation.
How similar studies have gone: Other research has shown promise in using multidimensional approaches to classify complex diseases, indicating potential for success in this novel approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Limbrick, David Delmar — Washington University
- Study coordinator: Limbrick, David Delmar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.