Understanding Chiari Malformation and its effects on brain development
Official title: Clinical Core
Funded at Washington University · NIH-10876263 · Data updated 2026-11-12
This study is looking for people with Chiari Malformation to join in and share their health experiences, so we can learn more about how this condition affects the brain and overall well-being, and help improve future treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $299,736 |
| NIH project number | 5P01NS131131-02 |
| Project ID | NIH-10876263 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include adolescents and adults diagnosed with Chiari Malformation.
✕Less likely to help
Patients without a diagnosis of Chiari Malformation or related neurological conditions may not benefit from this research.
What this research studies
This research focuses on Chiari Malformation (CM) and involves screening and enrolling participants to gather clinical data and neurobehavioral assessments. Patients will be recruited from Washington University and associated hospitals, and their health-related quality of life will be evaluated through various measures. The study aims to create a comprehensive registry and databases to support ongoing projects related to CM, including a clinical trial and genetic studies. By collecting and analyzing this data, the research seeks to better understand how CM affects brain development and neurological outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Chiari Malformation.
How similar studies have gone: Previous research has shown success in similar approaches to understanding Chiari Malformation and its impacts, indicating a solid foundation for this study.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Limbrick, David Delmar — Washington University
- Study coordinator: Limbrick, David Delmar
Related research
Other NIH-funded projects on the same topics.
-
Using MRI to measure brain oxygen levels as an early sign of small vessel disease in the brain
This study is looking at how measuring oxygen levels in the brain with MRI can help spot early signs of small vessel disease, which is linked to memory problems and dementia, especially Alzheimer's, so if you're at risk due to age or high blood pressure, you might be able to participate in MRI scans to learn more about
-
Advanced Methods & Modeling for Better Patient Care
A funding opportunity focused on developing new modeling methods to improve health care for patients through better data use and analytics.
-
Advanced methods and modeling for health research at Washington University
A health research grant at Washington University funds new modeling methods to support future patient-focused studies.
-
Center for Research in Emerging Infectious Diseases: Epidemiology, Surveillance and Pathogenesis
A NIH program will study and monitor emerging viruses from the Midwest U.S. and three Asian sites to understand how they spread and affect people.
-
How Poverty and the Environment Affect Heart Disease in Haiti and Beyond
This grant studies how poverty-related factors like food insecurity, stress, and pollution contribute to heart disease and aims to follow a large group of adults to better understand and prevent the disease.
-
Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.