Understanding changes in the right ventricle due to pulmonary hypertension
Right ventricle remodeling in pulmonary hypertension
This study is looking at how the right side of the heart changes when someone has high blood pressure in the lungs, and it aims to find new ways to help people with heart problems related to this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11097888 on NIH RePORTER |
What this research studies
This research investigates how the right ventricle (RV) changes in response to pulmonary hypertension (PH), focusing on the unique biological characteristics of RV cardiac myocytes. By studying these cells, the research aims to uncover differences in contractility, calcium handling, and cell size during RV remodeling. The approach includes using animal models to explore these cellular changes and their implications for treatment. The ultimate goal is to identify novel therapeutic strategies that could improve outcomes for patients suffering from RV dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pulmonary hypertension, particularly those experiencing right ventricle dysfunction.
Not a fit: Patients with left ventricle dysfunction or those not diagnosed with pulmonary hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments specifically targeting right ventricle dysfunction in pulmonary hypertension, potentially improving patient outcomes.
How similar studies have performed: Previous research has indicated that understanding the distinct biology of the right ventricle can lead to improved treatment strategies, suggesting that this approach has potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Gorr, Matthew William — Ohio State University
- Study coordinator: Gorr, Matthew William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.