Understanding changes in the right ventricle due to pulmonary hypertension
Official title: Right ventricle remodeling in pulmonary hypertension
Funded at Ohio State University · NIH-11097888 · Data updated 2026-11-12
This study is looking at how the right side of the heart changes when someone has high blood pressure in the lungs, and it aims to find new ways to help people with heart problems related to this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $48,386 |
| NIH project number | 3R01HL167963-01A1S1 |
| Project ID | NIH-11097888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pulmonary hypertension, particularly those experiencing right ventricle dysfunction.
✕Less likely to help
Patients with left ventricle dysfunction or those not diagnosed with pulmonary hypertension may not benefit from this research.
What this research studies
This research investigates how the right ventricle (RV) changes in response to pulmonary hypertension (PH), focusing on the unique biological characteristics of RV cardiac myocytes. By studying these cells, the research aims to uncover differences in contractility, calcium handling, and cell size during RV remodeling. The approach includes using animal models to explore these cellular changes and their implications for treatment. The ultimate goal is to identify novel therapeutic strategies that could improve outcomes for patients suffering from RV dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new treatments specifically targeting right ventricle dysfunction in pulmonary hypertension, potentially improving patient outcomes.
How similar studies have gone: Previous research has indicated that understanding the distinct biology of the right ventricle can lead to improved treatment strategies, suggesting that this approach has potential for success.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Gorr, Matthew William — Ohio State University
- Study coordinator: Gorr, Matthew William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.