Understanding changes in the right side of the heart in pulmonary hypertension
Official title: Right ventricle remodeling in pulmonary hypertension
Funded at Ohio State University · NIH-10999461 · Data updated 2026-11-12
This study is looking at how the right side of the heart changes in people with pulmonary hypertension, to better understand how it works differently from the left side and to find new treatments that could help improve heart health for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $444,122 |
| NIH project number | 5R01HL167963-02 |
| Project ID | NIH-10999461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pulmonary hypertension, particularly those experiencing right ventricle dysfunction.
✕Less likely to help
Patients with left ventricle dysfunction or those not diagnosed with pulmonary hypertension may not benefit from this research.
What this research studies
This research investigates how the right ventricle (RV) of the heart changes in patients with pulmonary hypertension (PH), a condition that can lead to serious heart problems. The study aims to uncover the unique biological processes occurring in the RV compared to the left ventricle (LV), which may respond differently to treatments. By using animal models and advanced techniques like transcriptomic analysis and flow cytometry, researchers will identify specific genes and immune responses involved in RV dysfunction. The ultimate goal is to develop targeted therapies that can improve outcomes for patients suffering from RV failure.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for patients with right ventricle dysfunction due to pulmonary hypertension.
How similar studies have gone: While there has been significant research on left ventricle dysfunction, this specific focus on right ventricle remodeling in pulmonary hypertension is relatively novel and has not been extensively tested.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Gorr, Matthew William — Ohio State University
- Study coordinator: Gorr, Matthew William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.