Understanding changes in brain circuitry in Parkinson's disease
Motor cortical circuitry adaptations in experimental Parkinson's disease
This study looks at how the loss of certain brain cells affects movement control in people with Parkinson's disease, helping us understand the changes that lead to motor symptoms and possibly guiding new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11010022 on NIH RePORTER |
What this research studies
This research investigates how the loss of dopamine-producing neurons in the brain affects the circuitry of the primary motor cortex, which is crucial for controlling movement. By examining the adaptations in specific types of neurons in this area, the study aims to uncover the underlying mechanisms that contribute to motor symptoms in Parkinson's disease. The research employs advanced techniques to analyze neuronal properties and synaptic changes, providing insights into how these adaptations may influence the progression of the disease. Patients may benefit from a better understanding of their condition and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease, particularly those experiencing motor symptoms.
Not a fit: Patients with Parkinson's disease who are in advanced stages or have significant comorbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for motor symptoms in Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in understanding brain circuitry adaptations in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Chu, Hong-Yuan — Georgetown University
- Study coordinator: Chu, Hong-Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.