Understanding changes in brain cells after hearing loss
Official title: Plasticity of auditory cortex microglia and perineuronal nets after hearing loss
Funded at Massachusetts Eye and Ear Infirmary · NIH-11109685 · Data updated 2026-11-12
This study is looking at how specific brain cells react to hearing loss, especially in people with conditions like hyperacusis, to find ways to help improve hearing and sound processing after ear injuries.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 6, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $194,400 |
| NIH project number | 5K08DC022004-02 |
| Project ID | NIH-11109685 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 who have experienced hearing loss or conditions like hyperacusis.
✕Less likely to help
Patients with normal hearing or those whose hearing loss is not related to central auditory processing issues may not benefit from this research.
What this research studies
This research investigates how certain brain cells and their surrounding structures respond to hearing loss, particularly focusing on conditions like hyperacusis. It examines the role of Parvalbumin positive interneurons and perineuronal nets in the auditory cortex, which may influence how the brain processes sound after cochlear injury. By studying these changes, the research aims to uncover potential mechanisms that could help restore normal auditory function. Patients may be involved in assessments to better understand their auditory processing and the effects of hearing loss.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hearing disorders, improving sound processing and quality of life for affected individuals.
How similar studies have gone: Previous research has shown promising results in understanding the role of microglia and perineuronal nets in auditory processing, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts Eye and Ear Infirmary
Boston, United States Active
Researchers
- Principal investigator: Kempfle, Judith — Massachusetts Eye and Ear Infirmary
- Study coordinator: Kempfle, Judith
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.