NIH-funded research Career grant

Understanding challenges and health effects of non-drug treatments for chronic pain when reducing opioid use

Official title: Barriers to and Health Consequences of Non- Pharmacological Chronic Pain Treatment among Patients Tapering Prescription Opioids in a Large Integrated Healthcare System

Funded at Columbia University Health Sciences · NIH-10927380 · Data updated 2026-11-12

This study is looking at the challenges and health effects for people who are reducing their use of prescription opioids and trying other ways to manage chronic pain, to better understand their experiences and find more effective treatments.

More Chronic Pain research and trials

Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionColumbia University Health Sciences
NIH-funded
Lab location1 site (New York, United States)
Project startSeptember 11, 2023
Project endAugust 31, 2028
Funding year2024
Award (this year)$133,100
NIH project number5K01AT012205-02
Project IDNIH-10927380 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adults over 21 years old who are currently tapering off prescription opioids and seeking alternative pain management strategies.

Less likely to help

Patients who are not currently using opioids or those who do not have chronic pain may not benefit from this research.

What this research studies

This research investigates the barriers and health consequences faced by patients who are tapering off prescription opioids and exploring non-pharmacological treatments for chronic pain. It aims to understand how these patients navigate their care and the effectiveness of alternative therapies. By utilizing electronic health records from a large healthcare system, the study will analyze patient experiences and outcomes related to opioid tapering. The findings could help improve treatment strategies for chronic pain management.

Why it matters

Potential benefit: If successful, this research could lead to better support and treatment options for patients managing chronic pain without relying on opioids.

How similar studies have gone: Previous research has shown success in exploring non-pharmacological treatments for chronic pain, indicating that this approach has potential for meaningful insights.

Where this research is happening

  • Columbia University Health Sciences
    New York, United States
    Active

Researchers

  • Principal investigator: Mannes, Zachary L — Columbia University Health Sciences
  • Study coordinator: Mannes, Zachary L

Related research

Other NIH-funded projects on the same topics.

  • Motor cortex tricks to ease chronic pain

    A study in rodents and people tests whether non-invasive brain stimulation of the motor cortex can reduce chronic pain and how best to target it.

    NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11621209

  • Human pain center study to map normal and migraine-trigeminal neurons

    A large NIH-funded project will map and study the human trigeminal neurons involved in migraines to understand what changes in these cells during headache conditions.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615140

  • Understanding human pain neurons to improve migraine care

    Researchers are studying human pain-sensing neurons to uncover what makes migraine start and persist, with the goal of better treatments for people who experience migraines.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615139

  • Whole Person Pain Algorithm to personalize chronic pain care

    A new, evidence-based model helps explain why chronic low back pain affects people differently and could guide personalized diagnosis and treatment.

    NIH research University of Florida · Gainesville, United States · NIH-11609318

  • Understanding how to use pharmacogenomic testing to guide chronic pain care

    This grant looks at how doctors who treat long‑term pain decide when and how to use genetic testing to tailor pain medicines for safer and more effective care.

    NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11602241

  • Mindfulness and Self-Hypnosis for Pain in Older Adults

    This grant tests non-drug ways like mindfulness and self-hypnosis to help people over 60 manage chronic pain.

    NIH research University of Washington · Seattle, United States · NIH-11599794

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.