Understanding cerebrospinal fluid flow in Huntington's disease
Cerebrospinal fluid dynamics in Huntington's disease
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11062117
This study is looking at how the fluid around your brain and spine works in people with Huntington's disease, and it hopes to find out if new treatments can help improve this fluid flow and overall health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11062117 on ClinicalTrials.gov |
What this research studies
This research investigates how cerebrospinal fluid (CSF) is produced, transported, and absorbed in patients with Huntington's disease. By using advanced neuroimaging techniques, the study aims to understand the effects of abnormal CSF circulation on the progression of the disease. The research also explores the potential impact of new treatments, specifically antisense oligonucleotides, on CSF dynamics and patient outcomes. Collaborations among neurologists and imaging experts enhance the study's approach to understanding neurodegeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Huntington's disease who are 21 years or older.
Not a fit: Patients with other neurological conditions unrelated to Huntington's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with Huntington's disease by optimizing CSF flow and enhancing the effectiveness of new therapies.
How similar studies have performed: Previous research has shown promising results in understanding neurofluid dynamics in other neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CLAASSEN, DANIEL OLIVER — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: CLAASSEN, DANIEL OLIVER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.