Understanding cerebrospinal fluid flow in Huntington's disease
Official title: Cerebrospinal fluid dynamics in Huntington's disease
Funded at Vanderbilt University Medical Center · NIH-11062117 · Data updated 2026-11-12
This study is looking at how the fluid around your brain and spine works in people with Huntington's disease, and it hopes to find out if new treatments can help improve this fluid flow and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $621,073 |
| NIH project number | 1R01NS141191-01 |
| Project ID | NIH-11062117 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with Huntington's disease who are 21 years or older.
✕Less likely to help
Patients with other neurological conditions unrelated to Huntington's disease may not benefit from this research.
What this research studies
This research investigates how cerebrospinal fluid (CSF) is produced, transported, and absorbed in patients with Huntington's disease. By using advanced neuroimaging techniques, the study aims to understand the effects of abnormal CSF circulation on the progression of the disease. The research also explores the potential impact of new treatments, specifically antisense oligonucleotides, on CSF dynamics and patient outcomes. Collaborations among neurologists and imaging experts enhance the study's approach to understanding neurodegeneration.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with Huntington's disease by optimizing CSF flow and enhancing the effectiveness of new therapies.
How similar studies have gone: Previous research has shown promising results in understanding neurofluid dynamics in other neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Claassen, Daniel Oliver — Vanderbilt University Medical Center
- Study coordinator: Claassen, Daniel Oliver
Related research
Other NIH-funded projects on the same topics.
-
Understanding CAG repeat instability in Huntington’s disease
A Huntington’s disease study explores why the CAG repeat in the HTT gene becomes unstable and leads to earlier disease, aiming to uncover factors that influence when and how the disease starts.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.