Understanding cerebrospinal fluid flow in aging and Alzheimer's disease
Imaging brain-wide subarachnoid and perivascular cerebrospinal fluid flow in aging and Alzheimer's disease
This study is looking at how the fluid in your brain moves, especially as we age and in people with Alzheimer's, to see if understanding this flow can help us find better ways to treat the disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10890172 on NIH RePORTER |
What this research studies
This research aims to investigate how cerebrospinal fluid (CSF) flows in the brain, particularly in relation to aging and Alzheimer's disease (AD). By developing advanced imaging techniques, the study will explore CSF flow dynamics in areas of the brain that are crucial for clearing toxic proteins associated with AD. The goal is to better understand how disruptions in CSF flow may contribute to the progression of Alzheimer's and related dementias. Patients may benefit from insights that could lead to new treatment strategies targeting CSF flow and clearance.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, as well as healthy older adults for comparative analysis.
Not a fit: Patients with other neurological conditions unrelated to Alzheimer's disease may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new therapies for Alzheimer's disease and related dementias.
How similar studies have performed: While studies on CSF flow have been conducted in animals, this approach is novel in humans and aims to fill significant gaps in understanding CSF dynamics in the context of Alzheimer's disease.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dong, Zijing — Massachusetts General Hospital
- Study coordinator: Dong, Zijing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.