Understanding Cells That Surround Pancreatic Tumors
Origin, diversification and function of pancreatic cancer associated fibroblasts
['FUNDING_OTHER'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-11176368
This project aims to understand the different types of cells surrounding pancreatic tumors and where they come from, which could help us find new ways to fight the disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11176368 on ClinicalTrials.gov |
What this research studies
Pancreatic cancer is a very serious disease, partly because we don't have enough effective treatments. A key feature of these tumors is the presence of special cells called cancer-associated fibroblasts, or CAFs, which seem to help the cancer grow and resist treatment. This project explores where these CAFs come from, including their origins from fetal development, and how they change over time. We also want to learn how a specific signaling pathway, called Hedgehog, influences these cells and their role in tumor growth. By uncovering these details, we hope to find new ways to target these cells and improve pancreatic cancer treatments.
Who could benefit from this research
Good fit: Patients with pancreatic ductal adenocarcinoma might ultimately benefit from new treatments developed based on this foundational understanding.
Not a fit: Patients whose cancer does not involve these specific types of surrounding cells or pathways may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could identify new targets for therapies that specifically block the growth and spread of pancreatic cancer.
How similar studies have performed: This research builds upon preliminary findings regarding the fetal origin of these cells, suggesting a novel approach to understanding pancreatic cancer.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAN, LU — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: HAN, LU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.