Understanding cells that produce IL-31 in allergic skin conditions
Official title: Illuminating IL-31-producing cells in allergic skin disease
Funded at University of California, San Francisco · NIH-10729476 · Data updated 2026-11-12
This study is looking at certain cells in the skin that might be causing long-lasting inflammation in skin conditions, and by understanding how these cells work, the researchers hope to find better treatments for people dealing with these issues.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $161,500 |
| NIH project number | 1R03AR082948-01 |
| Project ID | NIH-10729476 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory skin diseases, particularly those responsive to IL-31.
✕Less likely to help
Patients with non-inflammatory skin conditions or those not affected by IL-31-related pathways may not benefit from this research.
What this research studies
This research investigates the role of IL-31-producing cells in chronic inflammatory skin diseases. By using advanced techniques like single-cell RNA sequencing and a specialized mouse model, the team aims to identify and characterize these cells and their interactions in the skin. The study will provoke skin inflammation using allergens to better understand the cellular dynamics involved. This knowledge could lead to improved treatments for patients suffering from various skin conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic inflammatory skin diseases.
How similar studies have gone: Previous research has shown promising results with biologics targeting IL-31 in clinical trials, indicating a potential for success in this area.
Where this research is happening
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University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Fassett, Marlys S — University of California, San Francisco
- Study coordinator: Fassett, Marlys S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.