Understanding cells that produce IL-31 in allergic skin conditions
Illuminating IL-31-producing cells in allergic skin disease
This study is looking at certain cells in the skin that might be causing long-lasting inflammation in skin conditions, and by understanding how these cells work, the researchers hope to find better treatments for people dealing with these issues.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10729476 on NIH RePORTER |
What this research studies
This research investigates the role of IL-31-producing cells in chronic inflammatory skin diseases. By using advanced techniques like single-cell RNA sequencing and a specialized mouse model, the team aims to identify and characterize these cells and their interactions in the skin. The study will provoke skin inflammation using allergens to better understand the cellular dynamics involved. This knowledge could lead to improved treatments for patients suffering from various skin conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammatory skin diseases, particularly those responsive to IL-31.
Not a fit: Patients with non-inflammatory skin conditions or those not affected by IL-31-related pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic inflammatory skin diseases.
How similar studies have performed: Previous research has shown promising results with biologics targeting IL-31 in clinical trials, indicating a potential for success in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Fassett, Marlys S — University of California, San Francisco
- Study coordinator: Fassett, Marlys S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.