Understanding cell structures in diseases using advanced sequencing techniques
Integrative network modeling of bulk and single-cell sequencing data to characterize multi-scale cell architecture
This study is looking at how we can mix different types of genetic information to learn more about how cells behave in sick tissues, which could help us find new ways to understand and treat diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10914887 on NIH RePORTER |
What this research studies
This research investigates how different types of sequencing data can be combined to better understand the complex architecture of cells in diseased tissues. By utilizing both bulk and single-cell sequencing data, the study aims to identify abnormal molecular changes and cell populations associated with diseases. The approach includes developing a new method for clustering cells based on their characteristics, which will help in understanding how these cells communicate and function within their environment. This could lead to insights into disease mechanisms and potential new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic diseases or disorders that affect cellular architecture.
Not a fit: Patients with non-genetic diseases or those not affected by cellular architecture issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for various genetic diseases.
How similar studies have performed: Previous research has shown promise in using integrated data approaches to understand complex diseases, indicating potential success for this novel methodology.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Song, Won-Min — Icahn School of Medicine at Mount Sinai
- Study coordinator: Song, Won-Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.