Understanding cell signals in conditions like Hennekam and Van Maldergem syndromes
Regulation and feedback in Fat/Dachsous signaling
This project explores how certain cell signals, similar to those involved in human conditions like Hennekam and Van Maldergem syndromes, control cell growth and organization.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11088884 on NIH RePORTER |
What this research studies
Our cells use complex signals to grow and organize properly, and problems with these signals can lead to serious health conditions. This project looks at how two specific proteins, called Fat and Dachsous, communicate within cells to control these important processes. We are using advanced lab techniques to discover how these proteins interact and influence other key cellular components. By understanding these basic mechanisms, we hope to learn more about the underlying causes of diseases like Hennekam and Van Maldergem syndromes, which are linked to similar protein issues in humans.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this work might seek individuals with conditions like Hennekam and Van Maldergem syndromes.
Not a fit: Patients without conditions related to Fat/Dachsous signaling or similar cellular growth and polarity defects would likely not see direct benefit from this specific basic science project.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of the cellular mechanisms behind certain neurological and multisystem disorders, potentially leading to new ways to address these conditions in the future.
How similar studies have performed: While the specific details of Fat and Dachsous regulation are not fully understood, the general pathways involved, like the Hippo and planar cell polarity pathways, are well-established in biological research.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Blair, Seth S — University of Wisconsin-Madison
- Study coordinator: Blair, Seth S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.