Understanding Cell Growth in Breast Cancer
Function and Mechanism of the Hippo-PI5P4K Axis for Growth Control
This project explores how specific proteins called PI5P4Ks and the Hippo pathway work together to control cell growth, especially in breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11126755 on NIH RePORTER |
What this research studies
Our bodies have natural ways to control how cells grow, and sometimes these controls go wrong, leading to diseases like breast cancer. This project looks closely at two key players, PI5P4K proteins and the Hippo pathway, which are important for managing cell growth and how cells use nutrients. We want to understand how these proteins are regulated and how they contribute to breast cancer development when they don't work correctly. By uncovering these basic mechanisms, we hope to find new ways to stop cancer cells from growing.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with breast cancer in the future by improving our understanding of the disease.
Not a fit: Patients seeking immediate new treatments would not directly benefit from this early-stage, basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new targets for developing treatments that specifically block breast cancer cell growth.
How similar studies have performed: While the Hippo pathway and PI5P4Ks are known to be involved in cancer, this specific connection and regulatory mechanism is a new area of focus.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Emerling, Brooke M — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Emerling, Brooke M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.