Understanding Cell Growth for New Breast Cancer Treatments
Novel regulation of the CDK4/Cdh1/Pin1 signaling axis for targeted breast cancer therapies
This research explores how certain proteins control cell growth, hoping to find new ways to stop breast cancer cells from multiplying.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11143681 on NIH RePORTER |
What this research studies
Our cells have a natural system that controls when they grow and divide, and sometimes this system goes wrong in cancer. This project looks closely at specific proteins, like Cdh1, CDK4, and Pin1, that act like traffic cops for cell division. We are learning how these proteins interact and how their activity is controlled, especially how CDK4 affects Cdh1 and how Pin1 then gets involved. By understanding these detailed steps, we aim to discover new targets that could lead to more effective treatments for breast cancer.
Who could benefit from this research
Good fit: This foundational research is for future patients with breast cancer who may benefit from new treatment options developed from these discoveries.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could identify new targets for drugs that specifically block breast cancer cell growth, leading to more effective and targeted therapies.
How similar studies have performed: This work builds upon existing knowledge of cell cycle regulation and introduces novel findings regarding the specific interactions of CDK4, Cdh1, and Pin1.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Dang, Fabin — Case Western Reserve University
- Study coordinator: Dang, Fabin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.