Understanding cell death in glaucoma and its connection to autophagy
Autophagy and Retinal Ganglion Cell Death in Glaucoma
This study is looking into how a process called autophagy affects the health of nerve cells in the eye that can be damaged by glaucoma, with the hope of finding new ways to protect your vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10912488 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind retinal ganglion cell (RGC) death in glaucoma, a leading cause of blindness. It focuses on the role of autophagy, a cellular process that helps maintain cell health by removing damaged components. By exploring how autophagy contributes to RGC survival or death, the research aims to identify potential neuroprotective treatments that could prevent vision loss. The study employs various biological models to analyze the effects of autophagy in the context of glaucoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glaucoma, particularly those experiencing progressive vision loss.
Not a fit: Patients with glaucoma who are already at an advanced stage of the disease with irreversible vision loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect retinal cells and preserve vision in glaucoma patients.
How similar studies have performed: Previous research has shown promising results in understanding autophagy's role in neurodegenerative diseases, suggesting potential for success in this area as well.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Liton, Paloma — Duke University
- Study coordinator: Liton, Paloma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.