Understanding Cell Communication in Vitiligo Skin
High Resolution Spatial Transcriptomics using seq-FISH+
This work aims to uncover how cells talk to each other in the skin of people with vitiligo, especially those with darker skin tones.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11159462 on NIH RePORTER |
What this research studies
We are looking closely at skin samples from individuals with vitiligo to understand the complex conversations happening between different cells. By using advanced technology, we can map out exactly where these cells are located and how they communicate within the skin. This helps us see how immune cells and pigment-producing cells interact in both affected and unaffected areas. Our goal is to gain a clearer picture of what causes the white spots in vitiligo and why they develop.
Who could benefit from this research
Good fit: This research is relevant for patients living with vitiligo, particularly those with darker skin who experience significant health disparities.
Not a fit: Patients without vitiligo or those not interested in the underlying biological mechanisms of the disease may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of vitiligo, paving the way for new and more effective treatments.
How similar studies have performed: Previous studies using single-cell analysis have revealed many cellular interactions in vitiligo, and this project uses an innovative platform to add crucial spatial information to those findings.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Harris, John E — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Harris, John E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.