Understanding Cell Communication in Development and Disease
Sending and transducing Hedgehog and Wnt signals
['FUNDING_OTHER'] · HARVARD MEDICAL SCHOOL · NIH-11057722
This work explores how cells send and receive important signals called Hedgehog and Wnt, which play a role in normal development and diseases like cancer and birth defects.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11057722 on ClinicalTrials.gov |
What this research studies
Our lab focuses on understanding the fundamental ways cells communicate using Hedgehog (Hh) and Wnt signals, which are vital for how bodies develop and maintain themselves. These signals are also deeply involved in the development of cancers and birth defects. We are particularly interested in how cells release these signals, how they travel to other cells, and how those receiving cells interpret the messages. By uncovering these basic mechanisms, we hope to lay the groundwork for new approaches to health challenges.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation at this stage, but future clinical applications could benefit patients with specific cancers or birth defects linked to these pathways.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this fundamental understanding of cell communication could lead to new strategies for treating cancers and birth defects where these signaling pathways are disrupted.
How similar studies have performed: This project builds upon recent discoveries by the lab regarding dedicated release pathways for these signals, suggesting a novel approach within an established field.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SALIC, ADRIAN — HARVARD MEDICAL SCHOOL
- Study coordinator: SALIC, ADRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Treatment, Cancers