Understanding Cell Communication in Asbestos-Related Lung Damage
Macrophage-fibroblast interaction is required for asbestos-induced toxicity
This project explores how two types of cells, macrophages and fibroblasts, talk to each other and how this communication might lead to lung damage from asbestos exposure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11136483 on NIH RePORTER |
What this research studies
Our bodies have many types of cells, including fibroblasts and macrophages, which usually work together to keep us healthy. This project looks closely at how these cells interact, especially when someone has been exposed to asbestos. We believe that the way these cells communicate can change their behavior and contribute to the development of asbestos-related lung problems. By understanding this cellular conversation, we hope to uncover new ways to protect the lungs from asbestos toxicity.
Who could benefit from this research
Good fit: Patients who have been exposed to asbestos or are experiencing asbestos-induced lung conditions may find this research relevant.
Not a fit: Patients whose lung conditions are not related to asbestos exposure would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target specific cell interactions to prevent or reduce lung damage caused by asbestos.
How similar studies have performed: While the direct role of this specific cell communication pathway in asbestos toxicity is being newly explored, other studies have shown that cell interactions are crucial in many disease processes.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Carter, a Brent — University of Alabama at Birmingham
- Study coordinator: Carter, a Brent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.