Understanding Cell Communication Channels
Ligand Gated Ion Channels Across Time and Space
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11145236
This research aims to understand how tiny channels in our cells open and close, which is important because problems with these channels contribute to many human diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11145236 on ClinicalTrials.gov |
What this research studies
Our cells use special channels, called ligand-gated ion channels, to communicate and respond to their environment. When these channels don't work correctly, it can lead to various human diseases. This project seeks to uncover the precise ways these channels open and close, a process called gating, and how other proteins help control their function. We also want to learn how medicines might affect these channels. By focusing on a specific type called AMPA receptors, we hope to build a strong foundation for developing new treatments.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future clinical applications could benefit individuals with diseases linked to faulty cell communication channels.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical trial would not find a direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide crucial insights into how certain diseases develop and pave the way for new medications that specifically target these cellular channels.
How similar studies have performed: While the fundamental role of these channels is known, the precise, rapid mechanisms of their function and regulation, especially concerning therapeutics, remain largely unexplored.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TWOMEY, EDWARD C — JOHNS HOPKINS UNIVERSITY
- Study coordinator: TWOMEY, EDWARD C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.