Understanding Cell Changes Linked to Cancer and Aging
Mechanisms linking replication stress to genome instability in fission yeast
['FUNDING_OTHER'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11045706
This research helps us understand how changes in our cells, which are linked to conditions like cancer and aging, happen.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11045706 on ClinicalTrials.gov |
What this research studies
Our cells' genetic material can change, leading to problems like cancer, birth defects, and aging. This project uses a simple organism, fission yeast, which shares many genetic similarities with human cells, to see how these changes occur. By watching these yeast cells closely, we can learn how they respond when their DNA is under stress. This helps us discover how cells protect themselves and repair damage, which is vital for preventing disease.
Who could benefit from this research
Good fit: This foundational laboratory work does not directly involve patients, but it aims to uncover basic biological processes relevant to human health.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat diseases like cancer by targeting the fundamental processes that cause cell instability.
How similar studies have performed: Other studies in various organisms have shown that DNA replication stress is a key factor in genome instability, providing a strong foundation for this work.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FORSBURG, SUSAN L — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: FORSBURG, SUSAN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers