Understanding CDH1 Genes and Gastric Cancer in Hispanic/Latino Patients
Determining the role of germline CDH1 variants in gastric cancer outcome disparities in Hispanic/Latino patients
This research looks into how changes in a gene called CDH1 might affect stomach cancer outcomes for Hispanic/Latino patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11128689 on NIH RePORTER |
What this research studies
Many Hispanic/Latino patients experience stomach cancer at a younger age and often develop a more aggressive form of the disease, but we don't fully understand why. This project explores if specific changes in the CDH1 gene could be a key reason for these differences. Researchers are working to identify these genetic changes and learn how they influence the disease. By understanding these genetic links, we hope to better explain why stomach cancer affects Hispanic/Latino patients differently.
Who could benefit from this research
Good fit: Ideal candidates for future related studies might include Hispanic/Latino patients diagnosed with stomach cancer, especially the diffuse type, or those with a family history of the disease.
Not a fit: Patients without stomach cancer or those not of Hispanic/Latino descent may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to better ways to identify Hispanic/Latino patients at higher risk for aggressive stomach cancer and guide more personalized prevention or treatment strategies.
How similar studies have performed: This research builds on initial findings from the first genomic analysis of Hispanic/Latino stomach cancer patients, suggesting a novel approach to understanding health disparities.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Wang, Sam C. — Ut Southwestern Medical Center
- Study coordinator: Wang, Sam C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.