Understanding CD73 in Esophageal Healing for Eosinophilic Esophagitis
The role of CD73 in esophageal epithelial homeostasis
This project looks at how a specific cell type, called CD73+ cells, helps the esophagus heal in people with Eosinophilic Esophagitis (EoE).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11193283 on NIH RePORTER |
What this research studies
Many people with Eosinophilic Esophagitis (EoE) struggle with current treatments, and their esophageal lining often remains damaged. This damage, where the protective barrier of the esophagus is disrupted, is a key problem in EoE and makes it hard to manage symptoms. Our team is exploring a special group of cells, called CD73+ progenitor cells, found in the esophagus. We believe these cells are crucial for repairing and renewing the esophageal tissue. By learning more about how these cells work and why they are reduced in EoE, we hope to find new ways to help the esophagus heal.
Who could benefit from this research
Good fit: This foundational research is relevant for patients living with Eosinophilic Esophagitis, particularly those whose esophageal lining does not heal effectively with existing treatments.
Not a fit: Patients without Eosinophilic Esophagitis or related esophageal conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help repair the damaged esophageal lining in patients with EoE, especially those who don't respond well to current therapies.
How similar studies have performed: Our team's previous work has identified the importance of CD73+ cells in esophageal tissue renewal, providing a foundation for this deeper investigation into their role in EoE.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Muir, Amanda Brooke — Children's Hosp of Philadelphia
- Study coordinator: Muir, Amanda Brooke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.