Understanding CD14 and High Blood Pressure from Salt
CD14 and Salt-Sensitive Hypertension
['FUNDING_R01'] · AUGUSTA UNIVERSITY · NIH-11126673
This project explores how a protein called CD14 might protect against high blood pressure caused by salt, especially in women.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-11126673 on ClinicalTrials.gov |
What this research studies
High blood pressure, particularly when sensitive to salt, is a major health concern worldwide, leading to heart, brain, and kidney problems. Our team found a new way the body might fight high blood pressure involving a protein called CD14, which seems to work differently in females. We believe CD14 in kidney immune cells helps reduce harmful inflammation and free radicals, which could lessen salt-sensitive high blood pressure. This work builds on our discovery that removing CD14 in animal models led to worse high blood pressure and kidney damage, especially in females.
Who could benefit from this research
Good fit: This foundational research is for patients interested in the underlying causes of salt-sensitive high blood pressure and related cardiovascular and kidney diseases.
Not a fit: Patients seeking immediate new treatments or direct clinical trial participation would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat salt-sensitive high blood pressure, potentially with different approaches for men and women.
How similar studies have performed: This project builds on the researchers' own novel observations regarding CD14's role in hypertension, making it a relatively new and specific area of investigation.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATTSON, DAVID L. — AUGUSTA UNIVERSITY
- Study coordinator: MATTSON, DAVID L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Vascular Disorders, Cardiovascular Diseases