Understanding Cannabinoid Receptors for New Medicines
Endocannabinoid Active Sites as Therapeutic Targets
['FUNDING_P01'] · NORTHEASTERN UNIVERSITY · NIH-11128502
This work aims to better understand how cannabinoid receptors in the body work to help create new medications for various health conditions.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHEASTERN UNIVERSITY (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11128502 on ClinicalTrials.gov |
What this research studies
Our bodies have natural systems that use cannabinoid receptors, called CB1 and CB2, which play a role in pain, inflammation, and other functions. This project builds on previous discoveries of compounds that can interact with these receptors. We are now working to fine-tune how these compounds affect the receptors, aiming to boost helpful actions while avoiding unwanted side effects. The goal is to develop new tools and early drug candidates that could lead to treatments for conditions like inflammatory and fibrotic disorders, and potentially alcohol dependence.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients, but future clinical trials stemming from this research could benefit individuals with inflammatory disorders, fibrotic conditions, or alcohol dependence.
Not a fit: Patients without conditions related to cannabinoid receptor function, such as inflammatory, fibrotic, or addiction disorders, may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the discovery and development of new therapeutic medications for conditions involving pain, inflammation, and addiction.
How similar studies have performed: This is a renewal of a program project, indicating that prior work in this area has yielded successful developments in understanding cannabinoid receptors and creating related compounds.
Where this research is happening
BOSTON, UNITED STATES
- NORTHEASTERN UNIVERSITY — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAKRIYANNIS, ALEXANDROS — NORTHEASTERN UNIVERSITY
- Study coordinator: MAKRIYANNIS, ALEXANDROS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.