Understanding Cancer's Genetic Changes for Better Care
Statistical methods for genomic analysis of heterogeneous tumors
This project creates new ways to look at the genetic information in cancer cells to help us better understand how tumors grow and respond to treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11112484 on NIH RePORTER |
What this research studies
Cancers are complex, with different types of cells and genetic changes within a single tumor. This makes it challenging to understand how they evolve and how best to treat them. Our team is developing advanced statistical tools to analyze both the genetic code (DNA) and gene activity (RNA) from tumor samples at the same time. By combining these two types of information, we hope to uncover new insights into how tumors change over time. This deeper understanding could lead to more personalized and effective treatments for patients.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit all cancer patients by improving the analysis of their tumor data.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from participating in this specific methodological grant.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how cancers evolve, which may help doctors predict how a patient's cancer will progress and respond to different therapies.
How similar studies have performed: While previous studies have analyzed genomic or transcriptomic data separately, this project develops novel integrative methods to combine both types of data for a more comprehensive understanding.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Wang, Wenyi — University of Tx Md Anderson Can Ctr
- Study coordinator: Wang, Wenyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.