Understanding cancer mutations using advanced genetic techniques
Systematic characterization of cancer variants using single-cell functional genomics
['FUNDING_OTHER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10795918
This study is looking at how different changes in cancer cells can influence how they act and respond to treatments, using a special technique to better understand these genetic differences and help improve cancer care.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10795918 on ClinicalTrials.gov |
What this research studies
This research investigates how different mutations in cancer cells affect their behavior and response to treatments. By utilizing a method called BEAT-seq, which combines CRISPR technology and single-cell RNA sequencing, the researchers aim to systematically characterize the effects of various cancer-associated genetic variants. This approach allows for the engineering of specific mutations and the measurement of their impact on cellular functions, providing insights into the complexities of cancer genetics.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with specific genetic mutations related to cancer, particularly those with hereditary or somatic variants.
Not a fit: Patients without identifiable cancer-related genetic mutations or those with non-genetic forms of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective cancer treatments by improving our understanding of how specific mutations influence therapy responses.
How similar studies have performed: Previous research has shown promise in using CRISPR and single-cell sequencing to understand cancer genetics, indicating that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NORMAN, THOMAS MAXWELL — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: NORMAN, THOMAS MAXWELL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.